Endothelial Glycocalyx Damage Coincides With Microalbuminuria in Type 1 Diabetes

Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes.

Chronic hyperglycemia underlies microvascular complications in patients with type 1 diabetes. The mechanisms leading to these vascular complications are not fully understood. Recently, we observed that acute hyperglycemia results in endothelial glycocalyx damage. To establish whether glycocalyx is associated with microvascular damage, we performed glycocalyx perturbation volume measurements in ...

Endothelial dysfunction is correlated with microalbuminuria in children with short-duration type 1 diabetes.

P atients with diabetes have increased risk of developing atherosclerotic diseases (1). In type 1 diabetes, vascular complications are more frequently identified after the 5th year of the disease. Ultrasound assessment of endothelial function is a noninvasive method for detecting early structural and functional atherosclerotic process in the arterial wall. Impaired flow-mediated dilatation (FMD...

Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.

Hyperglycemia is associated with increased susceptibility to atherothrombotic stimuli. The glycocalyx, a layer of proteoglycans covering the endothelium, is involved in the protective capacity of the vessel wall. We therefore evaluated whether hyperglycemia affects the glycocalyx, thereby increasing vascular vulnerability. The systemic glycocalyx volume was estimated by comparing the distributi...

Microalbuminuria in Type-1 diabetes mellitus.

[Microalbuminuria in patients with type 2 diabetes].

OBJECTIVE To identify microalbuminuria in patients with type 2 diabetes. MATERIAL AND METHODS A descriptive cross-section study was made in patients with type 2 diabetes with more than a year of evolution. Microalbuminuria was defined as the presence of 30 to 300 mg of albumin in urine of 24 hours. The socio-demographic characteristics, type of diet, exercise, type of antihypertensive and ora...